Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease

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Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

IMPORTANCE There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies. OBJECTIVE To determine whether creatine monohydrate was mo...

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Parkinson disease (PD) is a degenerative neurological disorder that affects 0.5- 1% of old people in western countries. It primarily affects mobility function, and associated with increasing disability over time. People with PD express bradykinesia, rigidity, tremor, progressive postural instability and muscle weakness as symptoms of PD. Various exercise programs, including resistance or aerobi...

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Abstract Background & Aims: In regard to the limited studies about the effect of creatine on exercise-induced inflammatory responses, the present study was conducted to identify the effect of creatine monohydrate loading on response of serum C-reactive protein (CRP), interleukin-6 (IL-6) and peripheral blood leucocytes following one bout downhill running in male mountain climbers. Methods: Twen...

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Objectives: The authors of this paper hypothesized that vibration stimulation applied by a vibratory orthosis improves balance in patients with Parkinson’s disease (PD). In this study we evaluate this hypothesis. Methods & Materials: Fourteen PD patients (12 male and 2 female) with mean age of 59.9±9.1 (±SD) years were participated in this cross- sectional study. Using Biodex balance system,...

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ژورنال

عنوان ژورنال: JAMA

سال: 2015

ISSN: 0098-7484

DOI: 10.1001/jama.2015.120